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Published online before print July 28, 2005, doi:10.1212/01.wnl.0000173835.12308.bb)
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Received March 21, 2005
Accepted June 3, 2005

Sildenafil increases cerebrovascular reactivity: A transcranial Doppler study

M. Diomedi MD*, F. Sallustio MD, B. Rizzato MD, F. Ferrante MD, G. Leone MD, E. Spera MD, M. Scarfini MD, and G. Bernardi MD

From the Fondazione Santa Lucia IRCCS, Rome (Drs. Diomedi and Bernardi), and the Neurological Clinic (Drs. Diomedi, Sallustio, Rizzato, Ferrante, Leone, and Bernardi) and Department of Urology (Drs. Spera and Scarfini), Tor Vergata University, Rome, Italy.


* To whom correspondence should be addressed. E-mail: marina.diomedi{at}uniroma2.it.

Abstract-- The authors performed a double-blind, placebo-controlled study in 28 patients to evaluate the effects of sildenafil on cerebral hemodynamics. A significant improvement of cerebrovascular reactivity, without any modification of other variables, was recorded 1 hour after the administration of 50 mg sildenafil. Further investigations are needed to evaluate whether cerebrovascular reactivity improvement could contribute to triggering sildenafil-induced migraine.




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S. Brenner, M. Diomedi, and F. Sallustio
Sildenafil increases cerebrovascular reactivity: A transcranial Doppler study
Neurology, May 9, 2006; 66(9): 1455 - 1456.
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Sildenafil increases cerebrovascular reactivity: A transcranial Doppler study
Steven Brenner
Neurology Online, 16 Jan 2006 [Full text]
Sildenafil may have potential for treatment of cerebral vasospasm in subarachnoid hemorrhage
Marina Diomedi, et al.
Neurology Online, 16 Jan 2006 [Full text]

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