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Published online before print April 9, 2008, doi:10.1212/01.wnl.0000294330.27058.61)
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Received June 8, 2007
Accepted September 18, 2007

Silver syndrome variant of hereditary spastic paraplegia. A locus to 4p and allelism with SPG4

A. Orlacchio MD, PhD*, C. Patrono BSc (Hons), F. Gaudiello MD, C. Rocchi MD, V. Moschella MD, R. Floris MD, G. Bernardi MD, and T. Kawarai MD

From the Laboratorio di Neurogenetica (A.O., C.P., G.B.), CERC-IRCCS Santa Lucia, Rome; Dipartimento di Neuroscienze (A.O., C.R., V.M., G.B.), and Dipartimento di Diagnostica per Immagini e Radiologia Interventistica (F.G., R.F.), Università di Roma "Tor Vergata", Rome, Italy; and Department of Neurology (T.K.), Hyogo Brain and Heart Center, Himeji City, Japan.


* To whom correspondence should be addressed. E-mail: a.orlacchio{at}hsantalucia.it.

Objective: To perform a clinical and genetic study of two large Italian families (RM-36 and RM-51) showing the cardinal clinical features of Silver syndrome (SS), a rare dominantly inherited form of hereditary spastic paraplegia (HSP) complicated by amyotrophy of the small hand muscles.

Methods: Clinical assessment including neurophysiologic, neuropsychological, and neuroimaging evaluations. Genetic studies included linkage and sequence analyses.

Results: Using a genome-wide survey in the RM-36 family, a novel locus (SPG38) has been identified and mapped within the 13.1-cM region on chromosome 4p16-p15 between markers D4S432 and D4S1599. The RM-51 family was linked to the SPG4 locus at 2p21-p24 and sequence analysis of SPG4 showed a novel frameshift mutation p.Asp321GlyfsX6. Clinical examination of the affected members carrying the mutation showed high frequency of additional clinical features including decreased vibration sense, pes cavus, temporal lobe epilepsy, and cognitive impairment.

Conclusions: This study demonstrates evidence of a novel locus SPG38 for Silver syndrome (SS) and suggests that genetic defects in SPG4 might lead to broad clinical features overlapped with those of SS.




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L. P. Rowland and T. D. Bird
Silver syndrome: The complexity of complicated hereditary spastic paraplegia
Neurology, May 20, 2008; 70(21): 1948 - 1949.
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