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Moebius syndrome

Lower motor neuron involvement and hypogonadotrophic hypogonadism

From the Medical Neurology Branch, National Institute of Neurological Diseases and Stroke, and the Endocrinology Branch, National Cancer Institute, Public Health Service, U.S. Department of Health, Education and Welfare, Bethesda, Maryland

SUMMARYA patient has been described with Moebius syndrome in whom there was clinical paralysis of the muscles supplied by the third, fourth, sixth, and seventh cranial nerves. Limb muscle biopsy studies and electromyography of the limb muscle suggest denervation of an "anterior horn cell" type of abnormality in the spinal cord. Moebius was also of the opinion that the syndrome was secondary to lower motor neuron abnormality and that the cord could be involved. The hypogonadism of our patient was secondary to a deficiency of gonadotropic hormone.

Dr. Olson's address is National Institutes of Health, Bethesda, Maryland 20014.

Submitted for publication Jan. 7, 1970; accepted Jan. 29, 1970.

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