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The effect of hemodialysis on the plasma cortisol and the electroencephalogram in uremia

From the Section of Neurology, Yale University School of Medicine, New Haven, Connecticut

SUMMARYThe effect of hemodialysis upon plasma cortisol levels and the electroencephalograms of uremic patients was examined with respect to the possible contribution of altered plasma cortisol to the dialysis-induced CNS dysequilibrium syndrome. It was concluded that alterations in plasma cortisol do not have a significant role in this syndrome. In addition, it was demonstrated that hemodialysis does alter, in time and amount, the pattern of cortisol secretion in uremic subjects. The alterations in cortisol secretion were not related to the uremic state or to the amount of fluid removed during dialysis. The value of frequent sampling during a dynamically changing situation was demonstrated. The results were discussed in relation to the central nervous system control of cortisol secretion.

Dr. Gallagher's address is Section of Neurology, Yale University School of Medicine, 333 Cedar Street, New Haven, Connecticut 06510.

This investigation was supported by U.S. Public Health Service grant 5-PO1-NB-06208.

Submitted for publication Jan. 2, 1970; accepted Jan. 16, 1970.

The excellent technical assistance of Mrs. Marie Pisano and MIS. Helen Feigenbaum is gratefully acknowledged. The generous advice of Prof. Gilbert H. Glaser, Prof. Franklin H. Epstein, and Prof. Thomas F. Gallagher throughout this study is deeply appreciated.