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The protein composition of the cerebrospinal fluid in acute necrotizing encephalitis An agar gel electrophoretic and immunoelectrophoretic study

From the Department of Neurology, Wilhelmina Gasthuis, University of Amsterdam, Amsterdam, The Netherlands

SUMMARYThe results of agar electrophoretic and immunoelectrophoretic studies of CSF proteins in acute necrotizing encephalitis are presented. Two of the 5 patients showed marked abnormalities in CSF protein composition, specifically a markedly increased gamma globulin fraction (up to 45%), 3 to 5 gamma subfractions, including one high-speed fraction, and reversal of the beta 1 to upsilon ratio. Immunoelectrophoresis disclosed an increase in medium-speed and high-speed IgG and IgA.

The serum was characterized by an increase in alpha globulins and beta-2 globulin. No abnormalities of significance were found in the acute stage of illness.

It is concluded that the duration of illness and the extent of the perivascular infiltrates are factors of significance in the occurrence of these severe changes in CSF protein composition in acute necrotizing encephalitis.

Dr. van Welsum's address is Neurological Department, Wilhelmina Gasthuis, Eerste Helmersstraat 104, Amsterdam-Oud west, The Netherlands.

Submitted for publication Dec. 23, 1969; accepted Jan. 15, 1970.

The authors wish to thank Dr. W. A. den Hartog Jager for clinical advice in the preparation of this paper.

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