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Serum and cerebrospinal fluid immunoglobulins in multiple sclerosis

From the Department of Neurology, Indiana University Medical Center, Indianapolis

SUMMARYThirty-seven aspects related to the pathophysiology of serum and CSF immunoglobulins, including electrophoresis, immunoelectron-phoresis, CSF cytomorphology, and determination of the concentration of serum and CSF immunoglobulins, were studied in 64 patients with multiple sclerosis. The studies support the assumption that in addition to the immunopathological manifestations carried by immunocompetent cells in the CNS structures of patients with multiple sclerosis, the extraneural lymphoreticular system exhibits an abnormal activity, at least during certain phases of the disease.

From our experiences in electrophoretic, immunochemical, and cytomorphological examinations of over 900 patients with different neurological diseases, no specific manifestations were observed which might allow, per se, the diagnosis of MS.

Dr. Kolar's address is Department of Neurology, Indiana University Medical Center, 1100 West Michigan Street, Indianapolis, Indiana 46202.

Supported by USPHS grant NB 05450

Submitted for publication March 2, 1970; accepted March 16, 1970.

The authors are indebted to Dr. Charles Spurgeon for the assistance in assembling clinical data; to Miss M. OConnel, Miss C. Aleyea, and Mrs. D. Alhright for technical assistance; to Mrs. E. Solow (Department of Neurosurgery) for the ultraviolet spectrophotometric determination of total proteins; to Mr. J. Glore for drawing; and to MI. J. Demma for photography.

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