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Diphenylhydantoin and the cations and phosphates of electrically stimulated brain slices

From the Division of Neurology, Department of Medicine, University of Washington School of Medicine, Seattle

SUMMARYSlices prepared from guinea pig cerebral cortex were incubated in bicarbonate-buffered media. Slices which were electrically stimulated at 1,000 cps lost K⁺ and gained Na⁺. Contents of ATP and creatine phosphate fell during stimulation. These effects were all diminished by 1 to 5 . 10^–4 molar diphenylhydantoin. Diphenylhydantoin appears to diminish energy consumption by decreasing the downhill movements of monovalent cations that occur upon repeated membrane depolarization.

Dr. Swanson's address is University of Washington School of Medicine, Seattle, Washington 98105.

Submitted for publication Jan. 23, 1970; accepted Jan. 29, 1970.

We are grateful to Mrs. L. Anderson for skillful technical assistance. This work was supported by USPHS grants NB 05067 and NB 05424. Peter Crane's work was supported in part by funds from the Washington State Heart Associaation.

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