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NEUROLOGY 1970;20:765
© 1970 American Academy of Neurology

The ultrastructure of circulating immunocytes in Guillain-Barré syndrome

John N. Whitaker, M.D., Asao Hirano, M.D., Stuart D. Cook, M.D. and Peter C. Dowling, M.D.

From the Saul Korey Department of Neurology, Unit for Research in Aging, and Department of Pathology, Albert Einstein College of Medicine, and Laboratory Division, Montefiore Hospital and Medical Center, Bronx, New York

SUMMARYA large population of primitive basophilic mononuclear cells (immunocytes), capable of synthesizing DNA, occurs in the peripheral blood of patients with GBS. In this study, the electron-microscopic features of these circulating atypical mononuclear cells were correlated with their autoradiographic and light-microscopic characteristics. Circulating immunocytes in GBS have ultrastructural features which are consistent with their high metabolic activity and are indistinguishable from some of the cells infiltrating the nerve roots in GBS. This provides further evidence that these cells may play an important role in GBS pathogenesis.

Drs. Cook's and Dowling's address is New York Neurological Institute, 710 West 168th Street, New York, New York 10032.

Read by title at the meeting of the American Academy of Neurology, Washington, D.C., April 1969.

This investigation was supported by grant No. 559-A-1 from the National Multiple Sclerosis Society and Public Health Service grants HD 00674 and NB 03356.

Submitted for publication Oct. 24, 1969; accepted Nov. 3, 1969.




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S. D. Cook, P. C. Dowling, M. R. Murray, and J. N. Whitaker
Circulating Demyelinating Factors in Acute Idiopathic Polyneuropathy
Arch Neurol, February 1, 1971; 24(2): 136 - 144.
[Abstract] [PDF]