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Somatosensory recovery functions in multiple sclerosis patients

From the Department of Medicine, Division of Neurology, UCLA School of Medicine, Los Angeles.

SUMMARYThe somatosensory evoked response amplitured and latency recovery functions have been determined in 11 normal subjects and 10 patients with MS. The results show [1] no difference in the amplitude recovery between the groups and [2] a significant shortening of the patient test stimulus latency at shorter interstimulus times.

These results suggest that:

1. Diseased or demyelinated axons cannot effectively respond to a test stimulus that follows a conditioning stimulus by short intervals (less than 60 msec).
   
2. The more heavily myelinated and fastest conducting fibers are selectively more affected by the demyelination process.
   
3. The application of this method holds promise for assessing neuronal conduction in MS patients in comparison to normal subjects.
   

Dr. Namerow's address is Division of Neurology, University of California Center for the Health Sciences, Los Angeles, California 90024.

This work was supported in part by USPHS grant NS-08711 and National Multiple Sclerosis Society grant 516-C-3.

Submitted for publication Aug. 8, 1969; accepted Sept. 24, 1969.

The author is indebted to Mr. Nelson Enns for his assistance in performing this study and to Misses Lynn Ikoma and Barbara Citron for their assistance in processing the tapes and preparing the manuscript.

This article has been cited by other articles:

				J. A. Sharpe, W. F. Hoyt, and M. A. Rosenberg Convergence-Evoked Nystagmus: Congenital and Acquired Forms Arch Neurol, March 1, 1975; 32(3): 191 - 194. [Abstract] [PDF]