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Chromosome analysis of glioblastoma multiforme

From the Division of Neurological Surgery, University of California Medical Center, San Francisco

SUMMARYEleven glioblastomas were submitted for chromosome analysis. Satisfactory cells were obtained from 3 as fresh tumor tissue and from the remainder after short periods in cell cultures. The predominant pattern was a near-diploid karyotype, with most frequent deviations occurring in Group 6-12. A review of earlier reports and results of the present study indicate the frequent occurrence of the above pattern in glioblastomas, with some tumors also containing an additional population of near-tetraploid cells. One established glioblastoma cell line had a hypotriploid karyotype and 4 marker chromosomes.

Dr. Wilson's address is Division of Neurological Surgery, University of California Medical Center, San Francisco, California 94122.

Supported in part by grant CA 07859-04 from the National Cancer Institute, National Institutes of Health

Submitted for publication Feb. 6, 1969; resubmitted Aug. 13, 1969; accepted Sept. 15, 1909.

The authors express their debt of gratitude to Dr. Jacqueline Whang who kindly reviewed the material presented in this paper.