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Central nervous system mumps A review of 64 cases

From the Epidemiology Research Center, Florida State Board of Health, Tampa, Florida, the Departments of Behavioral Sciences and Audiology, University of South Florida, Tampa, and the National Communicable Disease Center, Public Health Service, U.S. Department of Health, Education and Welfare, Atlanta, Georgia

SUMMARYWe have reviewed 64 cases of documented central nervous system mumps which were referred to the Epidemiology Research Center for laboratory diagnosis between 1963 and 1968. Fifty-five were classified as mumps viral meningitis and 9 as meningoencephalitis. The average time interval between onset of parotitis and the development of CNS symptoms was 2.7 days, and mumps viral complement-fixing antibodies reached a geometric mean peak level of 1:96 between two and three weeks after onset of mumps illness. Follow-up neurological, psychometric, and audiometric performance tests on 19 patients revealed no significant differences between the patients and a group of matched controls, although one of those with meningoencephalitis had suggestive evidence of minimal brain damage.

Dr. Levitt's address is Department of Neurology, Children's Hospital Medical Center, 300 Longwood Ave., Boston, Massachusetts 02115.

Submitted for publication Oct. 28, 1969; accepted Nov. 17, 1969.

The authors gratefully acknowledge the assistance of Mrs. Shirley McLendon, Public Health Nurse, Epidemiology Research Center, Tampa, Florida, who located most of the patients for the follow-up study, and Dr. Donald Quick, Assistant Professor of Medicine (Neurology), University of Florida College of Medicine, Gainesville, Florida, who assisted in the investigation of some of the clinical cases.

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