HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Correspondence: Submit a response Alert me when this article is cited Alert me when Correspondence are posted Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by WHITAKER, J. N. Articles by ENGEL, W. K. Search for Related Content PubMed PubMed Citation Articles by WHITAKER, J. N. Articles by ENGEL, W. K.

A search for antibodies to neuronal nuclei in the serum of patients with myasthenia gravis

Medical Neurology Branch, National I nstitute of Neurological Disedscs and Stroke, Bethesda (Dr Engel), and the Neurology Service, Minneapolis Veterans Hospital and the University of Minnesota Medical School, Minneapolis (Dr. Whitaker).

To determine whether antibodies against spinal cord motor neurons are present in patients with myasthenia gravis, sera from 17 such patients were tested by indirect immunofluorescence. Although an-tinuclear antibody activity was detected in some patients, it was not restricted to neuronal nuclei. The study failed to confirm a previous report of specific antineuronal antinuclear antibodies in myasthenia gravis.

This study was supported in part by a grant froin the Minneapolis Veterans Administration Hospital.

Dr. Whitaker's address is Neurology Service, Memphis Veterans Hospital, and University of Tennessee College of Medicine, 62 South Dunlap, Memphis 38163

Received for publication June 26, 1973.

This article has been cited by other articles:

				R. R. Almon, C. G. Andrew, and S. H. Appel Serum Globulin in Myasthenia Gravis: Inhibition of agr-Bungarotoxin Binding to Acetylcholine Receptors Science, October 4, 1974; 186(4158): 55 - 57. [Abstract] [PDF]