HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Correspondence: Submit a response Alert me when this article is cited Alert me when Correspondence are posted Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by WELCH, K.M.A. Articles by LANCE, J. W. Search for Related Content PubMed PubMed Citation Articles by WELCH, K.M.A. Articles by LANCE, J. W.

Simultaneous measurement of internal and external carotid blood flow in the monkey

An approach to the study of migraine mechanisms

Division of Neurology, The Prince Henry Hospital and School of Medicine, University of New South Wales, Sydney, Australia. This work was supported by grants of N.H. and M.R.C. Australia and Sandoz (Australia) Ltd. Dr. Spira was a Commonwealth Postgraduate Scholar and Charles Robert McNiven Research Fellow. Miss Knowles was an N.H. and M.R.C. Rcscarch Assistant.

Internal and external carotid blood flow was simultaneously measured in monkeys. The experimental technique, which was validated by observations on response of the intracranial and extracranial vasculature to CO2 inhalation, hypertension, sympathetic stimulation, and the cerebral vasodilator, papaverine, appears to be an improved approach to the study of migraine mechanisms in the animal model. lntracarotid serotonin was shown by this method to constrict both the internal and external carotid arteries. This effect was prevented by intracarotid methysergide, which itself produced only a transient constriction of the same vessels.

Dr. Welch's address is Department of Neurology, Baylor College of Medicine, Houston, TX 77025.

Received for publication August 27, 1973.