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Reserpine in experimental cerebral edema

Further observations

Department of Pathology, Rush-Preshyterian-St. Luke's Medical Center, Chicago.

Focal areas of hemorrhagic necrosis were produced in the brains of anesthetized rhesus monkeys by freezing through the intact skull. Half of the animals were given reserpine beginning one hour after injury, and all animals were killed 24 hours after injury. The edema associated with the lesions was assessed by various methods. The animals receiving reserpine showed significantly less edema than controls as judged by water changes in the damaged hemisphere and significantly less hemorrhage in the lesion as determined from changes in tissue iron. This was not accompanied by a decrease in serum albumin uptake but the uptake of Evans blue was diminished. Body temperature and systemic blood pressure were decreased in the reserpine-treated animals.

Dr. Clasen's address is Department of Pathology, Presbyterian-St. Luke's Hospital, 1753 W. Congress Parkway, Chicago, IL 60612.

Read at the seventy-first annual meeting of the Association of Pathologists and Bacteriologists, San Francisco, March 1974.

This work was supported by NINDS grant NS 03677 and by the Otho S. A. Sprague Memorial Institute.

Received for publication January 3, 1974.