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Demonstration of specific antineuronal nuclear antibodies in sera of patients with myasthenia gravis

Indirect and direct immunofluorescence

Departments of Anatomy, Neurology, and Physiological Chemistry, University of Wisconsin Medical Center, Madison.

This report describes the successful application of indirect immunofluorescent analysis to the defection of selective antineuronal nuclear antibodies present in the sera of patients with myasthenia gravis. Because some commercial fluorescein isothiocyanate (FITC)-labeled antihuman gamma globulins possess antinuclear binding capacity, it is necessary to demonstrate that such reactivity is not present in the antihuman FITC-IgA, IgG, or IgM used for evaluating the sera from patients with myasthenia gravis.

Dr. Kornguth's address is Department of Neurology, University of Wisconsin Medical Center, 1300 University Avenue, Madison, WI 53706.

Supported by grants NS 5631 and NS 5604.

Received for publication January 30, 1974.