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Department of Neurobiology, Clinical Research Institute of Montreal and University of Montreal, Canada.
Thirty-five parkinsonian patients (five untreated, six with levodopa only, seven with levodopa plus Ro 4–4602, nine with anticholinergic and/or antihistaminic medication, and eight with the anticholinergic/antihistaminic medication plus amantadine) and 35 age-matched control subjects were studied. Platelets isolated from each individual plasma were incubated with 14C-dopamine. Uptake was found to be decreased to a significant degree in all treated or untreated parkinsonian patients when compared with control subjects. Anticholinergic and/or antihistaminic medication, with or without amantadine, further decreased the dopamine uptake into platelets, while levodopa alone or with Ro 4–4602 returned uptake values to near normal. Dopamine efflux paralleled exactly the uptake values. The fact that parkinsonian platelets exhibit impaired dopamine uptake, while age-matched control platelets do not, constitutes the first direct evidence in favor of a generalized dopamine defect in Parkinson's disease.
This paper was read at the twenty-sixth annual meeting of the American Academy of Neurology, San Francisco, April 1974.
Supported in part by MRC, Canada (Grant MA-4938), The United Parkinson Foundation, and the W. Garfield Weston Foundation.
Received for publication August 8, 1974.
Dr. Barbeau's address is Clinical Research Institute of Montreal, 110 Pine Avenue West, Montreal, Quebec, Canada H2W 1R7.
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