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Multiple sclerosis and elevation of cerebrospinal fluid vaccinia virus antibody

Departments of Neurology and Pediatrics, University of Utah Medical Center, Salt Lake City.

Thirty percent of 33 patients with a clinical diagnosis of multiple sclerosis and an elevation of cerebrospinal fluid (CSF) immunoglobulin G/albumin ratio greater than 2 standard deviations above the mean had elevation of the CSF vaccinia neutralizing antibody titer. Elevated titers were found in 1 of 23 patients with non-multiple sclerosis neurologic diseases and in none of the normal control patients. No linear correlation was found between the magnitude of the relative or absolute CSF immunoglobulin G concentration and the magnitude of the CSF vaccinia neutralizing antibody titers.

This study was supported in part by National Institutes of Health Training Grants 2 T1-NB 5503 and 2 T1-NB 5309, and by NINDS Special Fellowship 5 F11-NS-2447 NSRA.

An abstract of this paper was read before the twenty-sixth annual meeting of the American Academy of Neurology, April 27, 1974.

Received for publication July 2, 1974.

Dr. Thompson's address is Department of Neurology, University of Utah Medical Center, Salt Lake City, UT.

This article has been cited by other articles:

				J. M. Adams Measles and Vaccinia Antibodies in Multiple Sclerosis JAMA, August 18, 1978; 240(7): 637 - 637. [Abstract] [PDF]

				H. Miyamoto, J. E. Walker, A. H. Ginsberg, J. S. Burks, K. McIntosh, and C. H. Kempe Antibodies to Vaccinia and Measles Viruses in Multiple Sclerosis Patients Arch Neurol, June 1, 1976; 33(6): 414 - 417. [Abstract] [PDF]