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Neurofibrillary changes after acute experimental lead poisoning

Division of Neuropathology, Indiana University Medical Center, Indianapolis, Indiana.

Following acute tetraethyllead intoxication in rabbits classic neurofibrillary tangles develop. As studied by electron microscopy, such tangles develop in hydropic degenerating neurons and consist primarily of bundles of 200Å diameter smooth tubules of enormous length. In two of 16 animals a few twisted tubules (periodicity of 800 Å) also could be found. The significance of these lead-induced twisted tubules, so characteristic of Alzheimer's pre-senile dementia in man, is discussed.

This investigation was supported by U.S.P.H.S. research grants: ES 00900 and ES 01171.

Received for publication May 19, 1975.

Dr. Niklowitz's address is Division of Neuropathology, Indiana University School of Medicine, 1100 W. Michigan St., Indianapolis, IN 46202.

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