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NEUROLOGY 1975;25:935
© 1975 American Academy of Neurology

Cerebrospinal fluid acid-base and lactate changes after seizures in unanesthetized man

I. Idiopathic seizures

BENJAMIN RIX BROOKS, M.D. and RAYMOND D. ADAMS, M.D.

Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts.

The natural course of acid-base changes in arterial blood and lumbar cerebrospinal fluid of patients admitted after major motor seizures was correlated with simultaneously determined lactate levels. In 10 patients with idopathic seizures studied less than 3 hours after the seizure, arterial lactate and cerebrospinal fluid lactate were elevated in association with a mild arterial metabolic acidosis. The elevated cerebrospinal fluid lactate persisted despite a return to normal of the arterial lactate in seven patients studied between 3 and 6 hours after the seizure. All values were normal in five patients studied more than 4 days after a major seizure.

Read by title at the twenty-sixth annual meeting of the American Academy of Neurology, San Francisco, April 26, 1974.

Received for publication March 19, 1975.

Dr. Brooks' address is Medical Neurology Branch, National Institute of Neurological and Communicative Disorders and Stroke, National Institutes of Health, Bethesda, MD 20014.




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 Arch Intern MedHome page
G. W. Jordan, B. Statland, and C. Halsted
CSF Lactate in Diseases of the CNS
Arch Intern Med, January 1, 1983; 143(1): 85 - 87.
[Abstract] [PDF]


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