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Essential tremor

Treatment with propranolol

Department of Neurology, the University of Minnesota Health Sciences Center, Minneapolis.

A double-blind trial of propranolol, in a dosage of 120 mg a day, and placebo was conducted in 11 patients with essential tremor. An improvement in tremor was observed in all patients who received propranolol and was most pronounced in the upper extremities. The favorable clinical assessment was further confirmed by improvement in a grooved pegboard test and in the quality of handwriting as evaluated by two "blind" observers. No side effects were encountered. It is concluded that propranolol is at present the best available drug for the treatment of essential tremor.

Received for publication March 19, 1975.

Dr. Tolosa's present address is Mayo Box 468, the Department of Neurology, the University of Minnesota Hospital, Minneapolis, MN 55455.

This article has been cited by other articles:

				E. D. Louis Essential Tremor N. Engl. J. Med., September 20, 2001; 345(12): 887 - 891. [Full Text] [PDF]