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Effects of prostaglandins on cerebral blood vessels

Interaction with vasoactive amines

Division of Neuropathobgy, Medical College of Virginia, Richmond, Virginia.

Prostaglandins B₁ and B₂ were topically applied to the pial vessels of mice and arteriolar constriction was observed. This constriction could be significantly increased if serotonin was added to B₁, but not when norepinephrine was added. Response to B₂ was not enhanced by the simultaneous addition of either serotonin or norepinephrine. Earlier work with prostaglandin F₂ was replicated. F₂ constricted pial arterioles and a significantly greater constriction was produced when norepinephrine was applied simultaneously with Fza. The data suggest that among the causes of cerebral vasospasm one should consider not only the action of single agents, but also the combined effects of several agents that might be in contact with cerebral vessels.

This study was supported by HL-12775 and a grant from the John A. Hartford Foundation.

Received for publication February 1975.

Requests for reprints should be addressed to Dr. Rosenblum, Box 17, MCV Station, Richmond, VA 23298.