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Human muscle fiber fine structure

Morphometric data on controls

Department of Neurology and Neuromuscular Research Laboratory and the Department of Orthopedic Surgery, Mayo Clinic and Mayo Foundation, Rochester, Minnesota.

Muscle fiber fine structure was quantitatively analyzed in 70 longitudinally and 65 transversely sectioned fibers from 10 control subjects without weakness. The average mitochondrial fraction of the fiber volume is close to 4 percent and the mean size of a mitochondrion is about 0.1 µm². The sarcotubular surface area per unit fiber volume is close to 1.5 µm²/µm³ in transverse sections and 0.65 times this value in longitudinal sections. Only one-third of all fibers contain lipid droplets in the sectioned plane, and for all fibers the droplets account for approximately 0.12 percent of the fiber volume. Variations with the age and sex of the subjects and with different muscles were analyzed and the feasibility of typing human muscle fibers at the ultrastructural level was evaluated.

This work was supported in part by grant NS-6277 from the National Institutes of Health and by a Research Center Grant from the Muscular Dystrophy Association of America.

Received for publication August 22, 1974.

Reprint requests should be addressed to Dr. Engel, Department of Neurology, Mayo Clinic, Rochester, MN 55901.

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