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Effects of ketamine in epilepsy

Departments of Neurology and Anesthesiology, University of Wisconsin Center for Health Sciences, Madison.

Ketamine, a rapid-acting general anesthetic, was administered intravenously to 26 epileptics. The effects of ketamine on the patients' clinical seizures and electroencephalograms were compared with similar periods during alert and sleep states. Epileptic discharges were present in the alert electroencephalogram of 17 (65 percent) of the patients. Epileptic discharges were precipitated or aggravated by sleep in 15 patients (58 percent) and by ketamine in eight patients (31 percent). No seizures were recorded during ketamine anesthesia. Ketamine neither precipitates nor aggravates seizures and is less effective than natural sleep as an activator of epileptic discharges.

This investigation was supported by NIH grant NS-03360 and by a grant from Parke, Davis & Company.

An abstract of this paper was read at the twenty-sixth annual meeting of the American Academy of Neurology, San Francisco, April 1974.

Received for publication August 5, 1974.

Dr. Celesia's address is Department of Neurology, University of Wisconsin Center for Health Sciences, Madison, WI 53706.

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