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Cerebrovasculopathy following irradiation in childhood

Division of Child Neurology, the Neurological Institute of New York, Columbia-Presbyterian University Hospital, New York.

Symptomatic intracranial vasculopathy developed in four patients following irradiation for central nervous system tumors. All the patients presented with a stroke-like picture from 2 to 22 years after the completion of radiotherapy. Two of the patients showed abnormalities on arteriography consisting of narrowing of the supraclinoid portion of the internal carotid artery and the adjacent proximal anterior and middle cerebral arteries. Although the risks of radiotherapy for central nervous system tumors of malignant potential are outweighed by potential benefit, the risks should be carefully considered in cases of tumors with little or no malignant potential.

Read in part before the twenty-sixth annual meeting of the American Academy of Neurology, San Francisco, April 26, 1974.

Received for publication August 30, 1974.

Reprint requests should be addressed to Dr. Painter at Department of Pediatrics, Magee-Womens Hospital, Forbes Avenue and Halket Street, Pittsburgh, PA 15213.

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