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NEUROLOGY 1975;25:259
© 1975 American Academy of Neurology

The effect of alcohol on essential tremor

JOHN H. GROWDON, M.D., BHAGWAN T. SHAHANI, M.D., PH.D. and ROBERT R. YOUNG, M.D.

Department of Neurology and the Laboratory of Clinical Neurophysiology, Harvard Medical School and Massachusetts General Hospital, Boston.

Five patients with essential tremor had a dramatic diminution in tremor amplitude within 15 minutes of ingesting small doses of ethyl alcohol. The same patients were given equivalent amounts of ethyl alcohol infused into a brachial artery, and there was no decrease in tremor amplitude in the perfused limb. It is concluded that, in patients with essential tremor, ethanol acts in a specific fashion on sensitive structures within the central nervous system and has no effect on peripheral tremorogenic mechanisms. This provides additional evidence for a central mechanism in essential tremor, distinguishing it from other tremors arising primarily from oscillation in peripheral servo-loops.

Presented in part at the twenty-sixth annual meeting of the American Academy of Neurology, San Francisco, April 1974.

This study was supported by the Parkinson's Disease Project of the Massachusetts General Hospital and The Allen P. and Josephine B. Green Foundation. Dr. Growdon is Robert S. Schwab Fellow in Parkinson's Disease.

Received for publication August 30, 1974.

Dr. Young's address is Department of Neurology, Massachusetts General Hospital, Fruit Street, Boston, MA 02114.




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