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Internuclear ophthalmoplegia and associated abnormalities in eye motion timing (differential delays)

Studies of the dynamic characteristics of horizontal saccadic eye motion give velocity, acceleration, and timing information. Average time differences between the motion of the eyes on left and right gaze, termed "differential delays," are statistical measures of the average differences of right-going and left-going velocity waveforms, and can be determined to within 0.5 msec. These relative time measurements give information that is not necessarily apparent from the velocity or acceleration data, and provide a sensitive measure of early oculomotor dysfunction. Patients with internuclear ophthalmoplegia have been shown to give characteristic abnormal values, and two such patients are described in detail to illustrate how these measurements may be used both to help in diagnosis and to characterize the presumed lesions.

This study was supported by the research grant EY00885 from the Eye Institute, National Institutes of Health.

Received for publication July 22, 1974.

Reprint requests should be addressed to Dr. Fricker at Howe Laboratory of Ophthalmology, Harvard University Medical School, Massachusetts Eye and Ear Infirmary, 243 Charles Street, Boston, MA 02114.

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