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Clinical evaluation of eterobarb, a new anticonvulsant drug

Department of Neurology, Yale University, New Haven, Connecticut, and the Departments of Pharmacology and Neurology, Georgetown University, Washington, DC.

Two clinical investigations of a new anticonvulsant, eterobarb, N,N' dimethoxymethyl phenobarbital (DMMP), were conducted in separate geographic regions. The drug has considerable efficacy in reducing the frequency of partial seizures, with and without secondary generalization, as well as generalized tonic-clonic seizures. Sedation did not appear to be as prominent with this barbiturate as it was with phenobarbital or primidone.

This was presented in part at the twenty-fifth meeting of the American Academy of Neurology, Boston, April 1973.

This work was supported through the generosity of the Kendall Company, Lexington, Massachusetts, and by NIH grants to the clinical study centers at Yale University and Georgetown University.

Received for publication October 24, 1974.

Dr. Gallagher's address is Department of Pharmacology, Georgetown University Hospital, 3900 Reservoir Road, N.W., Washington, DC 20007.