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Cytoplasmic inclusion bodies in superior rectus muscle of the eye

Neurology and Neuropathology Services of the Boston Veteran's Administration Hospital, the Department of Neurology, Boston University School of Medicine (Dr. Culebras), and the Department of Pathology, Tufts University School of Medicine (Dr. Merk), Boston.

Cytoplasmic inclusion bodies are found in fibers of superior rectus muscle of the eye. They occur in middle-aged and old individuals dying with various unrelated diseases not affecting muscle and in patients with myotonic dystrophy. With light microscopy they can be observed in fibers with pathologic changes, and with electron microscopy they appear to be associated with crystals of probable viral origin. It is suggested that cytoplasmic inclusion bodies in superior rectus muscle are the result of viral activity and may represent an incidental viral infection of the senescent period.

This study was partially funded by USPHS grant CA 16377 to Dr. Merk.

This work was presented in part at the twenty-fourth annual meeting of the American Academy of Neurology, St. Louis, April 1972.

Received for publication September 4, 1974.

Dr. Culebras' address is Fundacion Jimenez Diaz, Avenida Reyes Catolicos 2, Madrid, Spain.

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