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A study of B and T cells in multiple sclerosis

Department of Neurology, Massachusetts General Hospital, and the Department of Neurology, Harvard Medical School, Boston.

Peripheral blood T and B lymphocytes were enumerated using E and EAC red blood cell rosetting techniques. The percentage of EAC-binding cells in peripheral blood of multiple sclerosis patients is elevated (31.7 ± 2.4 S.E.M.) when compared with the percentage in healthy controls (18.5 ± 1.1 S.E.M.). The total T cell percentage is not significantly lower in multiple sclerosis than in controls, but fewer T cells in patients with multiple sclerosis are able to bind 10 or more red blood cells.

This study was supported in part by NINDS grant NS06021, by a grant from the National Multiple Sclerosis Society, and by a Fellowship jointly sponsored by Harvard Medical School and the French Institut National de la Samé et de la Récherche Medical (Dr. Oger).

Presented in part at the twenty-sixth annual meeting of the American Academy of Neurology, San Francisco, April 1974.

Received for publication November 11, 1974.

Dr. Arnason's address is the Department of Neurology, Massachusetts General Hospital, Boston, MA 02114.