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Adolescent familial cramps

Department of Neurology (Child Neurology) and the Division of Neurosurgery, Albany Medical College, Albany, New York.

Two adolescent brothers were studied because of cramps in the legs following strenuous exercise. The symptoms were maximal at adolescence and later subsided. Serum creatine phosphokinase elevations were significant. Examination of muscle biopsy material revealed changes compatible with a myopathy. The family consists of seven children. All have eventually developed elevations of serum creatine phosphokinase, which appear to reach the highest point during adolescence. This familial disorder may represent a new myopathy with maximal penetrance at adolescence.

This study was supported in part by the Eleanor Roosevelt Developmental Services of the New York State Department of Mental Hygiene and the Veterans Administration Research Project 0822-01.

Presented at the twenty-third annual meeting of the American Academy of Neurology, New York, April 1973.

Received for publication August 15, 1974.

Dr. Hanson's address is Albany Medical College, 47 New Scotland Avenue, Albany, NY 12208.