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NEUROLOGY 1975;25:477
© 1975 American Academy of Neurology

Perivascular anoxia-ischemia lesions in the human brain

MICHAEL NOEL HART, M.D., GREGG M. GALLOWAY, B.S. and MARTIN J. DUNN, B.S.

Department of Pathology (Neuropathology), University of Missouri Medical Center, Columbia.

The clinical and pathologic data are presented on three patients who had clinical anoxia-ischemia in combination with serum hyperosmolality. The pathologic lesions consisted of perivascular necrosis, predominantly involving small vessels in the cerebral cortex. No intraluminal thromboembolic material was found in any of the vessels. The lesions are reminiscent of "no-reflow" lesions seen in experimental animals rendered ischemia

Received for publication October 18, 1974.

Dr. Hart's address is Department of Pathology (Neuropathology), University of Missouri Medical Center, Columbia, MO 65201.







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