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Department of Neurology, Mayo Clinic and Mayo Foundation, Rochester, Minnesota (Drs. Schoenberg and Whisnant) and the Chronic Disease Control Section, Connecticut State Department of Health, Hartford, Connecticut (Dr. Christine).
To determine whether nervous system neoplasms are associated with primary malignancies elsewhere, we studied the frequency of multiple primary tumors in patients in whom at least one of the primary tumors was within the nervous system. The patients were Connecticut residents with tumors diagnosed between 1935 and 1964. Of 135 patients, 130 had two primary tumors, four had three primary tumors, and one had four primary tumors. Only with multiple primary tumors involving the brain and breast did the number of observed cases significantly exceed the number of expected cases; eight patients who had a meningioma associated with a breast cancer accounted for this excess. Patients with breast cancer presenting with signs or symptoms of an intracranial neoplasm should be carefully evaluated, for the intracranial lesion may be a potentially curable meningioma.
This investigation was supported in part by a special traineeship award (5 F11 NS 02499-03 NSRB) to Dr. Schoenberg from the National Institute of Neurological Diseases and Stroke, Public Health Service.
Read in part before the twenty-sixth annual meeting of the American Academy of Neurology, San Francisco, April 25, 1974.
Received for publication January 28, 1975.
Requests for reprints should be addressed to Dr. Schoenberg, Section of Publications, Mayo Clinic, 200 First Street, S.W., Rochester, MN 55901.
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