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NEUROLOGY 1976;26:1130
© 1976 American Academy of Neurology

Dialysis encephalopathy

A possible seizure disorder

ALAN M. NADEL, M.D. and W. P. WILSON, M.D.

From the Epilepsy Unit, Division of Neurology, Department of Medicine, Veterans Administration Hospital (Dr. Nadel), and Department of Psychiatry, Duke University Medical Center (Dr. Wilson), Durham, North Carolina.

Dialysis encephalopathy is a progressive, fatal condition that occurs in patients receiving hemodialysis. It is characterized by abnormalities in speech, myoclonic jerks, and striking changes on the electroencephalogram. We observed dramatic reversal of the clinical symptoms and electroencephalographic abnormalities in four patients with this syndrome who were treated with diazepam. In this paper we propose that in dialysis encephalopathy, some of the symptoms and the electroencephalographic changes represent a form of seizure disorder.

Requests for reprints should be addressed to Dr. Nadel, 1314 Peabody Avenue, Memphis, TN 38104.

Received for publication January 5, 1976.




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