| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
From the Ophthalmogenetic Department of the Netherlands Ophthalmic Research Institute, Wilhelmina Gasthuis, Amsterdam; the Department of Ophthalmic Pathology, Erasmus University, Rotterdam; and the Department of Neuropathology, University of Nijmegen, and de Wever Ziekenhuis, Heerlen, The Netherlands.
A patient with Aicardi's syndrome had the complete clinical picture of mental subnormality, convulsions, electroencephalographic disturbances, ocular anomalies, female sex, and agenesis of the corpus callosum. A second patient had the features of the syndrome, with microphthalmia and one depigmented zone. In both cases and in Brihaye's case, no pineal gland was found. Since the epiphysis cerebri is important as a clock for sexual development, its absence may be incompatible with the development of a male fetus. The pathogenesis of the syndrome remains obscure. While an exogenous cause may be at work in some of the cases, the complex and stereotypical character of the symptoms plead for a hereditary origin.
Dr. de Jong's address is Netherlands Ophthalmic Research Institute, Wilhelmina Gasthuis, Eerste Helmersstraat 104, Amsterdam 1013, The Netherlands.
Received for publication December 1, 1975.
This article has been cited by other articles:
|
|
 |
|
  R. E. Frye, J. S. Polling, and L. C. K. Ma Choroid Plexus Papilloma Expansion Over 7 Years in Aicardi Syndrome J Child Neurol, April 1, 2007; 22(4): 484 - 487. [Abstract] [PDF]
|
|
|
|
 |
|
 T. Rosser Aicardi Syndrome Arch Neurol, October 1, 2003; 60(10): 1471 - 1473. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Flores-Sarnat Hemimegalencephaly: Part 1. Genetic, Clinical, and Imaging Aspects J Child Neurol, May 1, 2002; 17(5): 373 - 384. [Abstract] [PDF]
|
|
|
|
 |
|
 P. Gloor, J. S. Pulido, and G. F. Judisch Magnetic Resonance Imaging and Fundus Findings in a Patient With Aicardi's Syndrome Arch Ophthalmol, June 1, 1989; 107(6): 922 - 923. [PDF]
|
|
|
|
|
|
R. A. Del Pero, M. B. Mets, R. C. Tripathi, and E. Torczynski Anomalies of Retinal Architecture in Aicardi Syndrome Arch Ophthalmol, November 1, 1986; 104(11): 1659 - 1664. [Abstract] [PDF]
|
|
|
|
 |
|
 D. J. Lacey Agenesis of the Corpus Callosum: Clinical Features in 40 Children Arch Pediatr Adolesc Med, September 1, 1985; 139(9): 953 - 955. [Abstract] [PDF]
|
|
|
|
|
|
R. R. Clancy, M. B. Kurtz, D. Baker, J. T. Sladky, P. J. Honig, and D. P. Younkin Neurologic Manifestations of the Organoid Nevus Syndrome Arch Neurol, March 1, 1985; 42(3): 236 - 240. [Abstract] [PDF]
|
|
|
|
|
|
R. G. McMahon, R. A. Bell, G. R. W. Moore, and S. K. Ludwin Aicardi's Syndrome: A Clinicopathologic Study Arch Ophthalmol, February 1, 1984; 102(2): 250 - 253. [Abstract] [PDF]
|
|
|
|
|
|
H. Tachibana, A. Matsui, K. Takeshita, and T. Tamai Aicardi's Syndrome With Multiple Papilloma of Choroid Plexus Arch Neurol, March 1, 1982; 39(3): 194 - 194. [Abstract] [PDF]
|
|
|
|
 |
|
 D. A. Icenogle and A. M. Kaplan A Review of Congenital Neurologic Malformations Clinical Pediatrics, September 1, 1981; 20(9): 565 - 576. [Abstract] [PDF]
|
|
|
|
|
|
T. Kurokawa, K. Sasaki, T. Hanai, N. Goya, and S. Komaki Linear Nevus Sebaceus Syndrome: Report of a Case With Lennox-Gastaut Syndrome Following Infantile Spasms Arch Neurol, June 1, 1981; 38(6): 375 - 377. [Abstract] [PDF]
|
|
|
|
|
|
S. Chhabria Aicardi's Syndrome: Are Corticosteroids Teratogens? Arch Neurol, January 1, 1981; 38(1): 70 - 70. [Abstract] [PDF]
|
|
|
|
|
|
R. B. Lynn, D. C. Buchanan, G. M. Fenichel, and F. R. Freemon Agenesis of the Corpus Callosum Arch Neurol, July 1, 1980; 37(7): 444 - 445. [Abstract] [PDF]
|
|
|
|
|
|
R. G. Weleber, E. W. Lovrien, and J. B. Isom Aicardi's Syndrome: Case Report, Clinical Features, and Electrophysiologic Studies Arch Ophthalmol, February 1, 1978; 96(2): 285 - 290. [Abstract] [PDF]
|
|
|
|
|
|
C. S. Hoyt, F. Billson, and R. Ouvrier Ocular Features of Aicardi's Syndrome Arch Ophthalmol, February 1, 1978; 96(2): 291 - 295. [Abstract] [PDF]
|
|
|
|
|
|
J. R. Keane Suprasellar Tumors and Incidental Optic Disc Anomalies: Diagnostic Problems in Two Patients With Hemianopic Temporal Scotomas Arch Ophthalmol, December 1, 1977; 95(12): 2180 - 2183. [Abstract] [PDF]
|
|
|
|
|
|
R. G. Fariello, R. W. M. Chun, J. M. Doro, J. R. Buncic, and J. S. Prichard EEG Recognition of Aicardi's Syndrome Arch Neurol, September 1, 1977; 34(9): 563 - 566. [Abstract] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
