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Radiation-induced cerebrovascular disease in children

From the Department of Neurology, Children's Hospital Medical Center, Harvard Medical School, Boston, Massachusetts.

Radiation-induced internal carotid artery occlusion has not been well recognized previously as a cause of childhood cerebrovascular disease. A child who had received radiation as a neonate for a hemangioma involving the left orbit at the age of 6 years experienced a recurrent right-sided paresis, vascular headaches, and speech difficulties. Angiography showed a hypoplastic left carotid artery with occlusion of both the anterior and middle cerebral arteries. Collateral vessels bypassed the occluded-stenotic segments. Review of the literature showed two additional cases of large vessel occlusion in childhood associated with anastomatic telangiectatic vessel development following early radiation therapy of facial hemangioma.

This study was supported in part by NINCDS grant No. 5 TO1 NS05185-15.

Received for publication July 11, 1975.

Requests for reprints should be addressed to Dr. Bresnan, Department of Neurology, Children's Hospital Medical Center, 300 Longwood Avenue, Boston, MA 02115.

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