Neurology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text (PDF)
Right arrow Correspondence:
Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when Correspondence are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by SARNAT, H. B.
Right arrow Articles by LEWIS, J. E.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by SARNAT, H. B.
Right arrow Articles by LEWIS, J. E., JR.
NEUROLOGY 1977;27:550
© 1977 American Academy of Neurology

Effective treatment of infantile myasthenia gravis by combined prednisone and thymectomy

HARVEY B. SARNAT, M.D., JOHN D. McGARRY, M.B., M.R.C.P.I. and J. EUGENE LEWIS, JR., M.D.

Departments of Neurology (HBS and JDM), Pediatrics (HBS), and Surgery (JEL), Saint Louis University School of Medicine and Cardinal Glennon Memorial Hospital for Children, St. Louis, Missouri.

Attlcle abstract–Myasthenia gravis developed in two children at 2 and 3 years of age respectively. Minimal improvement followed chronic oral administration of cholinesterase inhibitors. Patient 1 had ptosis and ophthalmoplegia but no clinical or electromyographic involvement of muscles of the extremities, although a quadriceps muscle biopsy revealed lymphorrhages. Patient 2 had progressive generalized myasthenia for 31/2 years. Both children were given a 3-month course of prednisone followed by thymectomy. They both are in remission, 12 and 8 months after thymectomy, with only minimal residual ocular weakness, but this weakness is much more responsive to anticholinesterase drugs than before thymectomy. Long-term administration of steroids, with the attendant complication of growth retardation, is avoided.

Dr. Sarnat's address for reprints is Department of Neurology, 1221 S. Grand Blvd., St. Louis, MO 63104.

Received for publication April 14, 1976.




This article has been cited by other articles:


Home page
 J Child NeurolHome page
A. K. Afifi and W. E. Bell
Tests for Juvenile Myasthenia Gravis: Comparative Diagnostic Yield and Prediction of Outcome
J Child Neurol, October 1, 1993; 8(4): 403 - 411.
[Abstract] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1977 by AAN Enterprises, Inc.