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NEUROLOGY 1977;27:567
© 1977 American Academy of Neurology

Epileptogenic action of intraventricularly injected antimelatonin antibody

RUGGERO G. FARIELLO, M.D., GEORGE A. BUBENIK, M.D., GREGORY M. BROWN, M.D., Ph.D and LEE J. GROTA, Ph.D.

Clarke Institute of Psychiatry, Departments of Psychopharmacology and Neuroendocrinology, University of Toronto, Ontarlo, Canada, and Department of Psychiatry, University of Rochester, New York.

In rats, intraventricularly injected antimelatonin antibody caused the appearance of transitory epileptiform abnormalities. Epileptic activity arose from and was limited to the cortical mantle of the hemisphere ipsilateral to the injection side. The occasional occurrence of lateralized seizures has also been observed. Control injection of saline, of the vehicle (rabbit serum), or of antibody saturated with melatonin induced flattening and desynchronization of the electroencephalogram but not epileptiform activity. Repeated antimelatonin injections caused reappearance of the same type of epileptic abnormalities that lasted slightly longer than the first time. Melatonin may play an inhibitory role in neuronal excitability.

Dr. Fariello's address is EEG Laboratory, Department of Neurology, University of Wisconsin, 1954 East Washington Ave., Madison, WI 53706.

Received for publication July 9, 1976.




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