HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Correspondence: Submit a response Alert me when this article is cited Alert me when Correspondence are posted Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by RAJJOUB, R. K. Articles by OMMAYA, A. K. Search for Related Content PubMed PubMed Citation Articles by RAJJOUB, R. K. Articles by OMMAYA, A. K.

Granulomatous angiitis of the brain

A successfully treated case

Surgical Neurology Branch, National Institute of Neurological and Communicative Disorders and Stroke, Bethesda, Maryland.

A patient with clinical and radiographic findings initially suggesting a neoplasm was diagnosed as having Hodqkin disease. Computerized axial tomography demonstrated profound diffuse decreased density similar to that seen in cases of cerebral edema or leukomalacia. Cerebral angiography showed blood vessels with a beaded appearance. A diagnosis of granulomatous angiitis was made on the basis of brain biopsy specimens. Viral cultures were negative. Skin testing revealed poor responses to antigens. The patient improved dramatically following a combination of radiotherapy and steroid therapy. Resolution of the low-density abnormality seen on serial EMI scanning and resolution of the vasculitis demonstrated in the post-therapy brain biopsy specimen was dramatic. This is the first case of granulomatous angiitis of the brain diagnosed during life, and it points out the value of radiation and steroid therapy for relief of neurologic symptoms.

Dr. Ommaya's address is Surgical Neurology Branch, NINCDS. Bethesda, MD 20014.

Received for publication July 22, 1976.

This article has been cited by other articles:

				C. Salvarani, R. D. Brown Jr, K. T. Calamia, T.J.H. Christianson, J. Huston III, J. F. Meschia, C. Giannini, D. V. Miller, and G. G. Hunder Primary CNS vasculitis with spinal cord involvement Neurology, June 10, 2008; 70(24_Part_2): 2394 - 2400. [Abstract] [Full Text] [PDF]

				S. Shintani, S. Tsuruoka, N. Nagano, and T. Shiigai Transient Ischemic Attacks in Central Nervous System Vasculitis After Delivery: Case Report Vascular and Endovascular Surgery, January 1, 1993; 27(1): 62 - 66. [Abstract] [PDF]

				C. Vanderzant, M. Bromberg, A. MacGuire, and W. J. McCune Isolated Small-Vessel Angiitis of the Central Nervous System Arch Neurol, June 1, 1988; 45(6): 683 - 687. [Abstract] [PDF]

				D. S. Younger, A. P. Hays, J. C. M. Brust, and L. P. Rowland Granulomatous Angiitis of the Brain: An Inflammatory Reaction of Diverse Etiology Arch Neurol, May 1, 1988; 45(5): 514 - 518. [Abstract] [PDF]

				R. H. MILLER, J. J. S. CHEN, R. L NEY, and P. TUMULTY Granulomatous Angiitis Presenting with Polymyalgia Rheumatica and Abnormal Pituitary Function Ann Intern Med, February 1, 1985; 102(2): 210 - 211. [Abstract] [PDF]

				D. G. Rawlinson and C. W. Braun Granulomatous Angiitis of the Nervous System First Seen as Relapsing Myelopathy Arch Neurol, February 1, 1981; 38(2): 129 - 131. [Abstract] [PDF]

				B. D. Snyder and R. R. McClelland Isolated Benign Cerebral Vasculitis Arch Neurol, September 1, 1978; 35(9): 612 - 614. [Abstract] [PDF]