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Serum creatine phoshokinase and pyruvate kinase in neuromuscular disorders and Duchenne dystrophy carries

Division of Pediatric Neurology and the Departments of Neurology, Pediatrics, and Pathology, University of Utah College of Medicine, Salt Lake City, Utah.

Serum levels of creatine phosphokinase (CPK) and pyruvic kinase (PK) were determined on 42 controls, 57 patients with various neuromuscular disorders, and 23 female relatives of Duchenne dystrophy patients. CPK and PK enzyme activities were increased incomparable numbers of muscle disease patients and female carriers; there was no advantage in the combined use of the two tests. We did not confirm earlier reports suggesting that determination of PK is more valuable than CPK in carrier detection.

Reprint requests should be addressed to Dr. Ziter, Division of Pediatric Neurology, University of Utah College of Medicine, 50 North Medical Drive, Salt Lake City, Utah 84132.

Dr. Seay is a Postdoctoral Fellow of the Muscular Dystrophy Association.

This work was supported in part by a grant from the Muscular Dystrophy Association.

Accepted for publication October 18, 1977.