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Treatment of Huntington disease with a cholinergic agonist

Experimental Therapeutics Branch, National Institute of Neurological and Communicative Disorders and Stroke, National Institutes of Health, Bethesda, Maryland.

The involuntary movements of Huntington disease may be related to cholinergic hypofunction in the striatum. For this reason, the effect of a direct cholinergic agonist, are coline, was studied in six patients with this disorder. Rather than improving the chorea, are coline tended to exacerbate the choreic movements. Arecoline did produce significant alterations of blood pressure, heart rate, and body temperature, probably by central cholinergic stimulation.

Dr. Nutt's address is Department of Neurology, University of Oregon Health Sciences Center, Portland, OR 97201.

Presented in part at the thirtieth annual meeting of the American Academy of Neurology, Los Angeles, California, April 1978.

Accepted for publication January 6, 1978.

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