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Mitogen responsiveness and suppressor cell function in multiple sclerosis

Influence of age and disease activity

Department of Neurology, Pritzker School of Medicine, University of Chicago, Chicago, Illinois.

Mitogen responsiveness and suppressor cell function were determined in patients with multiple sclerosis. Mitogen response to concanavalin A, expressed as stimulation index, decreased with age in both patients and controls. Although responses in the overall group of young patients did not differ from controls, the stimulation index was reduced in clinically inactive patients. Patients with recent flare-ups showed responses comparable to controls. Suppressor cell activity increased with age in both disease and control groups. Among young patients, suppressor activity was borderline low in inactive patients but increased significantly in those with recent exacerbations.

Dr. Antel's address is Department of Neurology, University of Chicago, 950 East 59th Street, Chicago, IL 60637.

This study was supported in part by Grant No. RG 1130-A-14 from the National Multiple Sclerosis Society and by Grant No. PHS 1-R01 NS13526-01 Res. from the NINCDS.

Presented in part at the twenty-ninth annual meeting of the American Academy of Neurology, Atlanta, April 1977.

Accepted for publication August 4, 1977.

This article has been cited by other articles:

				M. R. Mickey, G. W. Ellison, J. L. Fahey, D. J. Moody, and L. W. Myers Correlation of Clinical and Immunologic States in Multiple Sclerosis Arch Neurol, April 1, 1987; 44(4): 371 - 375. [Abstract] [PDF]