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Active state properties ofdenervated and immobilized muscle

Comparison with dystrophic muscle

First Department of Internal Medicine, Nagasaki University School of Medicine, 7-1, Sakamoto-machi. Nagasaki, Japan.

Possible roles of neurotrophic mechanisms and muscle activity in the contractile abnormalities of muscular dystrophy were studied by comparing human dystrophic muscle to denervated and immobilized muscle. As evident in denervated muscle from the decreased acceleration of twitch development (decreased active state intensity of shortening), and isoproterenol-induced decrease of twitch with shortened decay of the active state, part of the abnormality in the subcellular calcium transport system in dystrophic muscle seems to be influenced by disordered neural regulation. Other active state abnormalities relating to activation processes and contractile proteins in dystrophic muscle were also demonstrated in both denervated and immobilized muscle, with some being more marked in immobilized muscle. The findings indicate that a neurogenic hypothesis cannot entirely explain the pathogenesis of progressive muscular dystrophy.

Reprint requests should be addressed to Dr. Takamori, First Department of Internal Medicine, Nagasaki University School of Medicine, 7-1, Sakamoto-machi. Nagasaki, Japan.

Presented in part at the Fifth International Scientific Conference of the Muscular Dystrophy Association, Durango, Colorado, June 1976.

Accepted for publication December 13, 1977.