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NEUROLOGY 1978;28:699
© 1978 American Academy of Neurology

Lergotrile in the treatment of parkinsonism

HAROLD L. KLAWANS, M.D., CHRISTOPHER G. GOETZ, M.D., PAUL VOLKMAN, M.D., PAUL A. NAUSIEDA, M.D. and WILLIAM J. WEINER, M.D.

Departments of Neurological Sciences and Phar macology, Rush-Presbyterian-St. Lukes Medical Center and Rush University (Drs. Klawans. Nausieda, and Weiner); Department of Neurological Sciences, Rush-Presbyterian-St. Lukes Medical Center (Dr. Goetz), Chicago, Illinois; and Department of Pediatrics, Loyola University Stritch School of Medicine, Maywood, Illinois (Dr. Volkman).

Lergotrile mesylate, a direct-acting dopamine agonist, was administered for up to 10 months to 25 patients with Parkinson disease. Of six patients not receiving levodopa concurrently, five showed definite improvement in parkinsonian signs and symptoms. These results are the first clear indication that lergotrile is efficacious, independently of any interaction with levodopa, in the treatment of Parkinson disease. The drug was also effective in relieving some complications of long-term levodopa therapy. Lergotrile was more effective in alleviating on-off problems than in reversing loss of levodopa efficacy. Side effects of lergotrile included exacerbation of hallucinations, dyskinesias, hypotension, and alterations in liver function tests.

Dr. Weiner's address is Department of Neurological Sciences, Rush-Presbyterian-St. Lukes Medical Center, 1753 West Congress Parkway, Chicago, IL 60612.

Presented in part at the twenty-ninth annual meeting of the American Academy of Neurology, Atlanta, April 1977.

This work was supported by a grant from Eli Lilly and Company, Indianapolis, Indiana.

Accepted for publication July 26, 1977.






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