HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Correspondence: Submit a response Alert me when this article is cited Alert me when Correspondence are posted Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by WEINER, W. J. Articles by KLAWANS, H. L. Search for Related Content PubMed PubMed Citation Articles by WEINER, W. J. Articles by KLAWANS, H. L.

The effect of levodopa, lergotrile, and bromocriptine on brain iron, manganese, and copper

Departments of Neurological Sciences and Pharmacology, Rush-Presbyterian-St. Luke's Medical Center, and Rush University, Chicago, Illinois.

Chronic administration of a levodopacarbidopa combination, bromocriptine, or lergotrile produced alterations of essential metal concentrations in the guinea pig caudate nucleus, frontal cortex, and cerebellar hemisphere. All long-term treatment regimens resulted in significantly increased concentrations of manganese in all brain areas, and these same regimens resulted in almost universally decreased copper concentrations. Since the long-term administration of these dopamine agonists in man results in extrapyramidal dysfunction, these observations suggest that alterations of trace metal concentrations in the brain may be related to the chronic toxicity of these dopamine agonists.

Dr. Weiner's address is Department of Neurological Sciences, Rush-Presbyterian-St. Luke's Medical Center, 1753 West Congress Parkway, Chicago, IL 60612.

This research was supported in part by grants from the United Parkinson Foundation, The Boothroyd Foundation, and the Michael Reese Medical Research Institute Council, Chicago, Illinois.

Accepted for publication August 15, 1977.

This article has been cited by other articles:

				Y.-Z. Chang, Y. Ke, J.-R. Du, G. M. Halpern, K.-P. Ho, L. Zhu, X.-S. Gu, Y.-J. Xu, Q. Wang, L.-Z. Li, et al. Increased Divalent Metal Transporter 1 Expression Might Be Associated with the Neurotoxicity of L-DOPA Mol. Pharmacol., March 1, 2006; 69(3): 968 - 974. [Abstract] [Full Text] [PDF]