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Cell-mediated immunity to measles, myelin basic protein, and central nervous system extract in multiple sclerosis

A longitudinal study employing direct buffy coat migration inhibition assays

Department of Neurology, Department of Medicine, and Division of Allergy and Immunology, School of Medicine, University of Pennsylvania, the Wistar Institute, and the Multiple Sclerosis Research Center of the University of Pennsylvania—Wistar Institute, Philadelphia, Pennsylvania.

Cell-mediated immunity to myelin basic protein, to an extract of central nervous system white matter, and to measles virus nuclear core, was studied in nine patients with multiple sclerosis in a serial longitudinal fashion using in vitro inhibition of buffy coat migration. The mean migration index to all antigens at various times before, during, and after exacerbation of multiple sclerosis in the patients did not differ from the index in a reference group of normal subjects. The incidence of inhibition of migration induced by central nervous system white matter and basic protein was greater than in serially studied normal subjects (p < 0.05, p < 0.2 > 0.1, respectively) but bore no definite relation to clinical course.

Dr. Lisak's address is Department of Neurology, School of Medicine, University of Pennsylvania, Philadelphia, PA 19104.

This study was supported by USPHS Grants No. 5 PO2 NS11037-04, 5 K07-NS11061-04, 5TO1-A107031, and National Multiple Sclerosis Grant No. 894-A-3.

Presented in part at the twenty-ninth annual meeting of American Academy of Neurology, Atlanta, April 1977.

Accepted for publication August 2, 1977.

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