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NEUROLOGY 1978;28:847
© 1978 American Academy of Neurology

Penicillamine-induced myasthenia gravis associated with antibodies to acetylcholine receptor

A. S. Russell and J. M. Lindstrom

Department of Medicine, University of Alberta, Edmonton, and The Salk Institute of Biological Studies, San Diego, California.

A woman with rheumatoid arthritis was treated with penicillamine and developed myasthenia gravis. This drug-induced disease was associated with characteristic autoantibodies to acetylcholine receptor. After discontinuing the drug, her symptoms improved and the antibody titers fell. Penicillamine is now being used much more frequently in the treatment of rheumatoid arthritis and it is likely that this complication will become more prevalent.

Dr. Lindstrom's address is Salk Institute of Biological Studies, P.O. Box 1809, San Diego, CA 921 12.

Accepted for publication August 12, 1977.




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