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NEUROLOGY 1979;29:1561-1565
© 1979 American Academy of Neurology

HLA types and immunity in multiple sclerosis

Barbara R. Visscher, M.D., D.P.H., Lawrence W. Myers, M.D., George W. Ellison, M.D., Roberta M. Malmgren, M.A., Roger Betels, M.D., Morris V. Lucia, M.D., David L. Madden, D.V.M.,Ph.D, John L. Sever, M.D., Ph.D., Min Sik Park, D.V.M. and Anne H. Coulson

From the School of Public Health, University of California, Los Angeles (Dr. Visscher, Ms. Malmgren, Dr. Detels, and Ms. Coulson), the Department of Neurology, School of Medicine, University of California, Los Angeles (Drs. Myers, Ellison, and Lucia), the National Institute of Neurological and Communicative Disorders and Stroke, National Institutes of Health, Bethesda, MD (Drs. Madden and Sever), and the Department of Surgery, School of Medicine, University of California, Los Angeles (Dr. Park).

HLA types and levels of humoral and cell-mediated immune responses to several antigens were studied in a large group of patients with multiple sclerosis, and in controls. Patients were more likely than controls to have the DKw2 antigen. They had higher mean antibody titers to measles but not to cytomegalovirus, herpes 1, or herpes 2, and had less competent cell-mediated responses. Antibody titers to measles were lower and cell-mediated immune responses were more effective in patients with the DRw2 antigen than in patients without it. This apparent specificity for measles suggests that the etiology of multiple sclerosis is related to the immune response to measles or related viruses.

This work was supported by Grant No. 2R01NS10186 from the National Institute of Neurological and Communicative Disorders and Stroke, National Institutes of Health. Computing assistance was obtained from the Health Sciences Computing Facility, UCLA, supported by NIH Special Research Resources Grant No. RR-3.

Addreso reprint requests to Dr. Visscher, School of Public Health, University of California, Los Angeles, CA 90024.

Accepted for publication May 3, 1979.






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