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Sensory kindling

Implications for development of sensory prostheses

From the Department of Psychology, University of Western Ontario, London, Ontario, Canada.

In designing sensory prosthetic implants that operate on the basis of direct electrical stimulation of the brain, the question of the plasticity of the tissue's response to the stimulation arises. Especially relevant is the kindling phenomenon, in which convulsions develop in response to repeated low-level electrical stimulation of the brain, including thalamic or neocortical primary sensory structures. Therefore, caution should be exercised in the development and application of prosthetic devices that directly activate brain tissue for long periods of time.

Supported by a grant from the National Research Council of Canada.

Address reprint requests to Dr. Cain, Department of Psychology, University of Western Ontario, London, Ontario, Canada N6A 5C2.

Accepted for publication May 1, 1979.

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