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Cerebrospinal fluid and serum immunoglobulins and C3 in Creutzfeldt-Jakob disease

From the Departments of Neurology and Biochemistry, Instituto de Neurocirugia e Investigaciones Cerebfales, Santiago de Chile.

We determined the concentrations of IgA, IgG, and C3 in spinal fluid and IgA, IgG, IgM, and C3 in serum from seven patients with histologically verified Creutzfeldt-Jakob disease. The mean total protein content in spinal fluid was significantly higher than in controls. The increased mean concentrations of IgA, IgG, and C3 in spinal fluid, and their respective mean percentages in spinal fluid, suggest a passage of IgG and C3 from blood into spinal fluid, and a possible production of IgA within the central nervous system.

Address reprint requests to Dr. Gálvez, P.O. Box 3717, Santiago de Chile.

Accepted for publication May 25, 1979.

This article has been cited by other articles:

				J. M. Bertoni, L. S. Label, J. C. Sackelleres, and S. P. Hicks Supranuclear Gaze Palsy in Familial Creutzfeldt-Jakob Disease Arch Neurol, October 1, 1983; 40(10): 618 - 622. [Abstract] [PDF]