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Dopaminergic antagonism of L-5-hydroxytryptophan-induced myoclonic jumping behavior

From the Department of Neurological Sciences, Rush-Presbyterian-St. Luke's Medical Center, Chicago.

We studied the effect of dopamine agonists (levodopa, apomorphine, lergotrile, and M-7 [2(dimethylamino)5,6-dihydroxytetralin] on myoclonic jumping behavior in young male guinea pigs. All these agents had a significant antagonistic effect on the frequency of this serotonin-mediated behavior. The duration of the antagonism corresponded in all cases to the duration of stereotyped chewing behavior induced by these agents alone. The dopamine antagonist haloperidol potentiated jumping behavior. Therefore myoclonic jumping behavior is influenced by dopaminergic mechanisms, and this behavior may be the result of interaction between dopaminergic and serotonergic activity. The role of dopaminergic mechanisms in human myoclonic disorders needs further clarification.

This work was supported in part by a grant from the United Parkinson Foundation and the Boothroyd Foundation, Chicago, Illinois.

Presented in part at the thirty-first annual meeting of the American Academy of Neurology, Chicago, IL, April 1979.

Address reprint requests to Dr. Weiner, Department of Neurological Sciences, Rush-Presbyterian-St. Luke's Medical Center, 1725 West Harrison Street, Chicago, IL 60612.

Accepted for publication May 8, 1979.

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